A major active metabolite of metamizole; inhibits A23187-induced PGE2 production in isolated mouse peritoneal macrophages at 0.1 mM; increases the paw withdrawal threshold in a rat model of carrageenan-induced hyperalgesia at 160 µg/paw; reduces LPS-induced pyrexia in rats at 60

4-Methylaminoantipyrine (hydrochloride) – 1 mg

Brand:
Cayman
CAS:
856307-27-2
Storage:
-20
UN-No:
Non-Hazardous - /

4-Methylaminoantipyrine is a major active metabolite of the non-opioid prodrug metamizole (Item No. 15771).{25749} It is formed from metamizole by non-enzymatic hydrolysis in the gastrointestinal tract.{57230} 4-Methylaminoantipyrine (0.1 mM) inhibits production of prostaglandin E2 (PGE2; Item No. 14010) induced by the calcium ionophore A23187 (Item Nos. 11016 | 22030) in isolated mouse peritoneal macrophages.{57231} It increases the paw withdrawal threshold in a rat model of carrageenan-induced hyperalgesia when administered at a dose of 160 µg/paw.{57232} 4-Methylaminoantipyrine (60, 90, and 120 mg/kg) reduces LPS-induced pyrexia in rats.{57233} It is also a potential impurity found in commercial preparations of metamizole.{57234}  

 

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Description

A major active metabolite of metamizole; inhibits A23187-induced PGE2 production in isolated mouse peritoneal macrophages at 0.1 mM; increases the paw withdrawal threshold in a rat model of carrageenan-induced hyperalgesia at 160 µg/paw; reduces LPS-induced pyrexia in rats at 60, 90, and 120 mg/kg; a potential impurity found in commercial preparations of metamizole

Formal name: 1,2-dihydro-1,5-dimethyl-4-(methylamino)-2-phenyl-3H-pyrazol-3-one, monohydrochloride

Synonyms:  Metamizole Impurity C

Molecular weight: 253.7

CAS: 856307-27-2

Purity: ≥95%

Formulation: A solid

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