A σ1 receptor ligand (Ki = 1.7 nM); selective for σ1 over σ2 receptors (Ki = 25.2 nM); inhibits the growth and migration of PC3 prostate cancer and A549 NSCLC cells

4-IBP – 5 mg

Brand:
Cayman
CAS:
155798-08-6
Storage:
-20
UN-No:
Non-Hazardous - /

4-IBP is a sigma-1 (σ1) receptor ligand (Ki = 1.7 nM).{61020,61021} It is selective for σ1 over σ2 receptors (Ki = 25.2 nM). It inhibits the growth and migration of PC3 prostate cancer and A549 non-small cell lung cancer (NSCLC) cells, as well as the migration of C32 melanoma and U373 MG glioblastoma cells, when used at a concentration of 10 µM.{61020} 4-IBP (2 mg/kg) increases survival in a U373 MG mouse xenograft model. It also increases firing of serotonergic neurons in the rat dorsal raphe nucleus when administered at a dose of 2 mg/kg.{61021}  

 

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SKU: 31518 - 5 mg Category:

Description

A σ1 receptor ligand (Ki = 1.7 nM); selective for σ1 over σ2 receptors (Ki = 25.2 nM); inhibits the growth and migration of PC3 prostate cancer and A549 NSCLC cells, as well as the migration of C32 melanoma and U373 MG glioblastoma cells, at 10 µM; increases survival in a U373 MG mouse xenograft model at 2 mg/kg; increases firing of serotonergic neurons in the rat dorsal raphe nucleus at 2 mg/kg

Formal name: 4-iodo-N-[1-(phenylmethyl)-4-piperidinyl]-benzamide

Synonyms:  NSC 667672

Molecular weight: 420.3

CAS: 155798-08-6

Purity: ≥98%

Formulation: A solid

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