A phenolic acid with anti-inflammatory activity; formed via microbial metabolism of aromatic amino acids and polyphenolic compounds

4-Hydroxyphenylacetic Acid – 100 g

Brand:
Cayman
CAS:
156-38-7
Storage:
-20
UN-No:
Non-Hazardous - /

4-Hydroxyphenylacetic acid is a phenolic acid with anti-inflammatory activity.{46255} It is formed via microbial metabolism of aromatic amino acids and polyphenolic compounds, including flavonoid glycosides, by gut microbiota.{46256,46257,46258} 4-Hydroxyphenylacetic acid (100 mg/kg) inhibits seawater instillation-induced increases in TNF-α, IL-1β, and IL-6 levels in lung tissue and white blood cell numbers in bronchoalveolar lavage fluid (BALF) and prevents lung edema in a rat model of acute lung injury.{46255} Levels of 4-hydroxyphenylacetic acid are increased and decreased in serum and urine, respectively, in rats fed a high-fat diet.{46256} Serum levels of 4-hydroxyphenylacetic acid are increased in patients with stage III pancreatic cancer.{46259}  

 

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Description

A phenolic acid with anti-inflammatory activity; formed via microbial metabolism of aromatic amino acids and polyphenolic compounds, including flavonoid glycosides, by gut microbiota; inhibits seawater instillation-induced increases in TNF-α, IL-1β, and IL-6 levels in lung tissue and white blood cell numbers in BALF and prevents lung edema in a rat model of acute lung injury at 100 mg/kg; levels are increased and decreased in serum and urine, respectively, in rats fed a high-fat diet; serum levels are increased in patients with stage III pancreatic cancer

Formal name: 4-hydroxy-benzeneacetic acid

Synonyms:  p-HPAA|p-Hydroxyphenylacetic Acid|4-HPAA|NSC 25066|NSC 27460

Molecular weight: 152.1

CAS: 156-38-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cancer||Research Area|Endocrinology & Metabolism|Bile Acids & Microbiome||Research Area|Immunology & Inflammation|Pulmonary Diseases

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