Description
A chalcone metabolite; estrogenic and cytotoxic in MCF-7 cells at concentrations higher than 100 nM; inhibits TNF-α-induced NF-κB signaling and the trypsin-, chymotrypsin-, and caspase-like proteolytic activities of the 26S proteasome in K562 cells in a dose-dependent manner; reduces growth of K562, U937, and Jurkat cancer cell lines in a dose-dependent manner without effecting viability of PBMCs; inhibits GSH-RD (IC50 = 47.3 μM) in vitro in a reversible and non-competitive manner
Formal name: 1-(4-hydroxyphenyl)-3-phenyl-2-propen-1-one
Synonyms: p-Cinnamoylphenol|2-Benzal-4′-hydroxyacetophenone|2-Benzylidene-4′-hydroxyacetophenone|NSC 242264
Molecular weight: 224.3
CAS: 2657-25-2
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Natural Products|Chalcones||Product Type|Biochemicals|Small Molecule Inhibitors|TNF-α/NF-κB Signaling||Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Cancer|Cell Death||Research Area|Cancer|Cell Signaling|NF-κB Signaling||Research Area|Cancer|Transcription Factors|NF-κB||Research Area|Cell Biology|Cell Signaling|NF-κB Signaling||Research Area|Cell Biology|Proteolysis|Ubiquitin/Proteasome System||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Toxicology|Drug Metabolism|Cytochrome P450||Research Area|Toxicology|Drug Metabolism|Drug Metabolites
