A metabolite of atorvastatin; formed by metabolism of atorvastatin by CYP3A4

4-hydroxy Atorvastatin lactone – 1 mg

Brand:
Cayman
CAS:
163217-70-7
Storage:
4
UN-No:
Non-Hazardous - /

4-hydroxy Atorvastatin lactone is a metabolite of atorvastatin (Item No. 10493), an HMG-CoA reductase inhibitor present in formulations that have been used to treat hypercholesterolemia and certain dyslipidemias.{18239,18240,18241,18235} Atorvastatin is metabolized by the cytochrome P450 (CYP) isoform CYP3A4 to form 4-hydroxy atorvastatin (Item No. 22575) and 2-hydroxy atorvastatin, which can be interconverted between their acid and lactone forms.{18239} Atorvastatin can itself be lactonized to atorvastatin lactone (Item No. 20951) then metabolized by CYP3A4 directly to 4-hydroxy atorvastatin lactone and 2-hydroxy atorvastatin lactone.  

 

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SKU: 23358 - 1 mg Category:

Description

A metabolite of atorvastatin; formed by metabolism of atorvastatin by CYP3A4,

Formal name: 5-(4-fluorophenyl)-N-(4-hydroxyphenyl)-2-(1-methylethyl)-4-phenyl-1-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1H-pyrrole-3-carboxamide

Synonyms:  p-hydroxy Atorvastatin lactone|para-hydroxy Atorvastatin lactone

Molecular weight: 556.6

CAS: 163217-70-7

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Cardiovascular System|Lipids & Lipoproteins|Cholesterol Metabolism||Research Area|Lipid Biochemistry|Sterol Lipids||Research Area|Toxicology|Drug Metabolism|Cytochrome P450||Research Area|Toxicology|Drug Metabolism|Drug Metabolites

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