A metabolite of the mycotoxin alternariol; formed through CYP450 metabolism; increases ROS in KYSE510 cells by 701% compared to control; increases topoisomerase IIβ-DNA complexes by 208% compared to control; does not induce DNA damage; completely inhibits topoisomerase Iiα activity at a concentration of 25 µM in a cell-free assay

4-hydroxy Alternariol – 5 mg

Brand:
Cayman
CAS:
959417-21-1
Storage:
-20
UN-No:
Non-Hazardous - /

4-hydroxy Alternariol is a metabolite of the mycotoxin alternariol (Item No. 11306) formed through cytochrome P450 (CYP450) metabolism.{41226} It increases reactive oxygen species (ROS) in KYSE510 human esophageal cells by 701% compared to control.{41227} 4-hydroxy Alternariol increases topoisomerase IIβ-DNA complexes by 208% compared to control in an ICE assay but does not induce DNA damage in KYSE510 cells. It completely inhibits topoisomerase IIα activity at a concentration of 25 µM under cell-free conditions.  

 

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SKU: 23636 - 5 mg Category:

Description

A metabolite of the mycotoxin alternariol; formed through CYP450 metabolism; increases ROS in KYSE510 cells by 701% compared to control; increases topoisomerase IIβ-DNA complexes by 208% compared to control; does not induce DNA damage; completely inhibits topoisomerase Iiα activity at a concentration of 25 µM in a cell-free assay

Formal name: 3,4,7,9-tetrahydroxy-1-methyl-6H-dibenzo[b,d]pyran-6-one

Synonyms:  4-hydroxy AOH|4-OH AOH

Molecular weight: 274.2

CAS: 959417-21-1

Purity: >95%

Formulation: A solid

Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Toxins|Mycotoxins||Research Area|Oxidative Stress & Reactive Species|Pro-oxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen

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