An alkylating agent that crosslinks DNA and induces T cell apoptosis; activates mitochondrial death pathways through production of ROS

4-hydroperoxy Cyclophosphamide – 1 mg

Brand:
Cayman
CAS:
39800-16-3
Storage:
-80
UN-No:
Non-Hazardous - /

4-hydroperoxy Cyclophosphamide (4-OOH-CY) is the active metabolite form of the prodrug Cyclophosphamide (Item No. 13849). 4-OOH-CY crosslinks DNA and induces T cell apoptosis independent of death receptor activation, but activates mitochondrial death pathways through production of reactive oxygen species (ROS).{34375} Formulations containing the prodrug Cyclophosphamide are used to treat lymphomas and autoimmune disorders.{22688,21833}  

 

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Description

An alkylating agent that crosslinks DNA and induces T cell apoptosis; activates mitochondrial death pathways through production of ROS,

Formal name: 2-[bis(2-chloroethyl)amino]tetrahydro-2-oxido-2H-1,3,2-oxazaphosphorin-4-yl, hydroperoxide

Synonyms:  4-OOH-CY

Molecular weight: 293.1

CAS: 39800-16-3

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|DNA Alkylating Agents||Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|Mitochondrial Biology||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Immunology & Inflammation|Autoimmunity

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