A metabolite of doxycycline; does not act as an antibiotic; an alternative to doxycycline for Tet-Off and Tet-On-based gene expression systems in vitro and in mice

4-Epidoxycycline – 500 µg

Brand:
Cayman
CAS:
6543-77-7
Storage:
-20
UN-No:
Non-Hazardous - /

4-Epidoxycycline is the 4-epimer hepatic metabolite of the antibiotic doxycycline (Item No. 14422).{41111,41110} Unlike doxycycline, 4-epidoxycycline lacks antibiotic activity, therefore, it may not induce the intestinal inflammation in mice associated with doxycycline use. It is an alternative to doxycycline to inactivate the transactivator protein tTA or activate the reverse transactivator rtTA protein in Tet-Off- and Tet-On-based gene expression systems in vitro and in mice.  

 

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SKU: 23225 - 500 µg Category:

Description

A metabolite of doxycycline; does not act as an antibiotic; an alternative to doxycycline for Tet-Off and Tet-On-based gene expression systems in vitro and in mice

Formal name: (4R,4aR,5S,5aR,6R,12aS)-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide

Synonyms:  4-ED

Molecular weight: 444.4

CAS: 6543-77-7

Purity: ≥70%

Formulation: A solid

Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors

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