A potential impurity found in commercial omeprazole and esomeprazole magnesium preparations

4-desmethoxy Omeprazole – 25 mg

Brand:
Cayman
CAS:
110374-16-8
Storage:
-20
UN-No:
Non-Hazardous - /

4-desmethoxy Omeprazole is a potential impurity found in commercial omeprazole and esomeprazole magnesium preparations. Omeprazole (Item No. 14880) is a selective and irreversible inhibitor of the gastric H+/K+ ATPase pump (IC50 = 1.1 μM).{14045} It is a racemic mixture of two enantiomers, (S)-omeprazole (esomeprazole magnesium; Item No. 17326) and (R)-omeprazole (Item No. 18874), which are prodrugs of the active sulfonamide which is formed by acid-stimulated conversion.{18256,18249} Both enantiomers are extensively metabolized by the cytochrome P450 (CYP) isomers CYP2C19 and CYP3A4.{18249}  

 

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Description

A potential impurity found in commercial omeprazole and esomeprazole magnesium preparations

Formal name: 2-[[(3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-6-methoxy-1H-benzimidazole

Synonyms:  4 desmethoxy OMEP|4 desmethoxy OMP|4 desmethoxy OMZ|Esomeprazol Magnesium Impurity B|Omeprazole EP Impurity B

Molecular weight: 315.4

CAS: 110374-16-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Pharmaceutical Impurities||Product Type|Biochemicals|Small Molecule Inhibitors|ATPases||Research Area

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