A vitamin B6 antimetabolite; inhibits transport of pyridoxine

4-deoxy Pyridoxine (hydrochloride) – 250 mg

Brand:
Cayman
CAS:
148-51-6
Storage:
-20
UN-No:
Non-Hazardous - /

4-deoxy Pyridoxine (DOP) is a vitamin B6 antimetabolite with diverse biological activities.{38612,38613,38614,38615,38616} It inhibits transport of pyridoxine (Item No. 20706), pyridoxal, and pyridoxamine in and reduces growth of S. carlsbergensis cells.{38612} DOP inhibits sphingosine-1-phosphate (S1P) lyase and reduces cyclic stretch-induced apoptosis in alveolar epithelial MLE-12 cells.{38613} DOP (5 mg, i.p.) reduces lysyl oxidase activity by 26% and reduces collagen and elastin crosslinking, resulting in limb abnormalities in chick embryos.{38614} It decreases latency to first seizure in mice (ED50 = 1 mmol/kg) and increases the occurrence and duration of myoclonic responses in baboons with photosensitive epilepsy.{38615} DOP reduces TNF-α and IL-6 production in mice infected with T. spiralis.{38616}  

 

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Description

A vitamin B6 antimetabolite; inhibits transport of pyridoxine, pyridoxal, and pyridoxamine in and reduces growth of S. carlsbergensis cells; inhibits S1P lyase and reduces cyclic stretch-induced apoptosis in alveolar epithelial MLE-12 cells; decreases latency to first seizure in mice (ED50 = 1 mmol/kg) and increases the occurrence and duration of myoclonic responses in baboons with photosensitive epilepsy; reduces TNF-α and IL-6 production in mice infected with T. spiralis,

Formal name: 5-hydroxy-4,6-dimethyl-3-pyridinemethanol, monohydrochloride

Synonyms:  4-Deoxypyridoxine|4-DPD|DOP

Molecular weight: 189.6

CAS: 148-51-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Sphingolipid Turnover||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Infectious Disease|Parasitic Diseases

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