An inhibitor of tubulin polymerization (IC50 = 13 μM); inhibits the growth of human HepG2 liver

4′-Demethylepipodophyllotoxin – 5 g

Brand:
Cayman
CAS:
6559-91-7
Storage:
-20
UN-No:
Non-Hazardous - /

4′-Demethylepipodophyllotoxin is an inhibitor of tubulin polymerization (IC50 = 13 μM).{48556} It inhibits the growth of human HepG2 liver, HeLa cervical, A549 lung, and BGC-823 stomach cancer cells in vitro (IC50s = 18.74, 15.96, 52.08, and 21.26 μM, respectively).{48557} 4′-Demethylepipodophyllotoxin also inhibits the growth of non-cancerous human HL-7702 liver cells (IC50 = 13.04 μM).  

 

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SKU: 28393 - 5 g Category:

Description

An inhibitor of tubulin polymerization (IC50 = 13 μM); inhibits the growth of human HepG2 liver, HeLa cervical, A549 lung, and BGC-823 stomach cancer cells (IC50s = 18.74, 15.96, 52.08, and 21.26 μM, respectively); inhibits the growth of non-cancerous human HL-7702 liver cells (IC50 = 13.04 μM)

Formal name: (5R,5aR,8aR,9S)-5,8,8a,9-tetrahydro-9-hydroxy-5-(4-hydroxy-3,5-dimethoxyphenyl)-furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one

Synonyms:  (−)-4′-Demethylepipodophyllotoxin

Molecular weight: 400.4

CAS: 6559-91-7

Purity: ≥98%

Formulation: A crystalline solid

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