4-CPPC is an inhibitor of macrophage migration inhibitory factor-2 (MIF-2; IC50 = 27 µM).{46807} It is selective for MIF-2 over MIF-1 (IC50 = 450 µM). It inhibits MIF-2, but not MIF-1, binding to CD74 in vitro when used at a concentration of 10 µM. 4-CPPC (5, 10, and 25 µM) inhibits MIF-2-induced ERK1/2 phosphorylation in primary human skin fibroblasts.
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A MIF-2 inhibitor (IC50 = 27 µM); selective for MIF-2 over MIF-1 (IC50 = 450 µM); inhibits MIF-2 binding to CD74 in vitro at 10 µM; inhibits MIF-2-induced ERK1/2 phosphorylation in primary human skin fibroblasts at 5, 10, and 25 µM
Formal name: 4-(3-carboxyphenyl)-2,5-pyridinedicarboxylic acid
Synonyms:
Molecular weight: 287.2
CAS: 29553-70-6
Purity: ≥95%
Formulation: A crystalline solid
The PtdIn phosphates play an important role in the generation and transduction of intracellular signals.{8344,4096,14518} PtdIns-(3,4,5)-P3-biotin is an affinity probe which allows the PIP3 to be detected through an interaction with the biotin ligand. This design allows PtdIns-(3,4,5)-P3-biotin to serve as a general probe for any protein with a high affinity binding interaction with inositol-(3,4,5)-triphosphate phospholipids, such as phosphatidylinositol 3-kinase, PTEN, or PH-domain-containing proteins.
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The PtdIn phosphates play an important role in the generation and transduction of intracellular signals.{8344,4096,14518} PtdIns-(3,4,5)-P3-biotin is an affinity probe which allows the PIP3 to be detected through an interaction with the biotin ligand. This design allows PtdIns-(3,4,5)-P3-biotin to serve as a general probe for any protein with a high affinity binding interaction with inositol-(3,4,5)-triphosphate phospholipids, such as phosphatidylinositol 3-kinase, PTEN, or PH-domain-containing proteins.
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The nuclear factor-κB (NF-κB) regulates the expression of numerous genes involved in immunity and inflammation, cellular stress responses, growth, and apoptosis. Resveratrol, a polyphenolic trans-stilbene, is a known inhibitor of the activation of NF-κB and exhibits activity against a wide variety of cancer cells. CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNFα-induced activation of NF-κB by CAY10512 is 0.15 µM compared to 20 µM by resveratrol.{14545}
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1,2-Dipalmitoyl-sn-glycero-3-PC (DPPC) is a zwitterionic glycerophospholipid commonly used in the formation of lipid monolayers, bilayers, and liposomes for use in a variety of applications.{14480,24261,14478,14479} It has been used in the formation of proteoliposomes for implantation of γ-glutamyl transpeptidase into human erythrocyte membranes.{14478} Incorporation of glycosphingolipid antigens into DPPC-containing liposomes increases the immunogenicity of the antigens in mice.{14479}
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