A bifunctional photoreactive agent for crosslinking nucleic acids; intercalates into double-stranded regions in DNA or RNA and

4′-Aminomethyl-4,5′,8-trimethylpsoralen – 1 mg

Brand:
Cayman
CAS:
64358-50-5
Storage:
-20
UN-No:
De Minimis - 1759 / 8

4′-Aminomethyl-4,5′,8-trimethylpsoralen is a bifunctional photoreactive agent for crosslinking nucleic acids.{28101,28103} In the dark, it intercalates into double-stranded regions in DNA or RNA. Upon long wavelength UV irradiation (e.g., 365 nm), 4′-aminomethyl-4,5′,8-trimethylpsoralen first forms a covalent monoadduct with a pyrimidine base, followed by covalently linking with an adjacent pyrimidine on the opposite strand.{28101,28103} Short wavelength UV irradiation (e.g., 254 nm) reverses this reaction. 4′-Aminomethyl-4,5′,8-trimethylpsoralen has a high binding affinity for RNA and has been used to study different types of RNA from diverse organisms, including viruses.{28099,28100,28102}  

 

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Description

A bifunctional photoreactive agent for crosslinking nucleic acids; intercalates into double-stranded regions in DNA or RNA and, upon UV irradiation, forms covalent adducts with pyrimidine bases; used to study different types of RNA from diverse organisms, including viruses

Formal name: 3-(aminomethyl)-2,5,9-trimethyl-7H-furo[3,2-g][1]benzopyran-7-one

Synonyms:  4′-Aminomethyltrioxsalen

Molecular weight: 257.3

CAS: 64358-50-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Labeling & Detection|Reactive Probes

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