An inhibitor of PARP (IC50 = 180 nM); blocks radiation-induced PARP in cancer cells

4-amino-1,8-Naphthalimide – 100 mg

Brand:
Cayman
CAS:
1742-95-6
Storage:
-20
UN-No:
Non-Hazardous - /

The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis, particularly in response to reactive oxygen and nitrogen species.{22577,22591} 4-amino-1,8-Naphthalimide (4-ANI) is an inhibitor of PARP (IC50 = 180 nM).{22573} It blocks radiation-induced PARP in cancer cells, potentiating the cytotoxicity of γ-radiation, although it is not cytotoxic in the absence of radiation.{29753} 4-ANI is used to study the role of PARP activity in various cell systems.{25755,29751,29752}  

 

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Description

An inhibitor of PARP (IC50 = 180 nM); blocks radiation-induced PARP in cancer cells, potentiating the cytotoxicity of γ-radiation, although it is not cytotoxic in the absence of radiation

Formal name: 6-amino-1H-benz[de]isoquinoline-1,3(2H)-dione

Synonyms:  4-Aminonaphthalimide|4-ANI

Molecular weight: 212.2

CAS: 1742-95-6

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|DNA Repair Enzymes||Research Area|Cancer|Cell Death||Research Area|Cancer|DNA Damage and Repair||Research Area|Epigenetics, Transcription, & Translation|RNA, DNA, & Protein Synthesis

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