An IRE1α inhibitor; inhibits IRE1α splicing of Xbp1 mRNA (IC50 = 6.8 µM); reduces Erdj4 gene expression downstream of IRE1α and Xbp1 (IC50 = 3.4 µM); does not block IRE1α autophosphorylation; reduces IL-4 production in CD4+ T cells; reduces LPS-stimulated increases in TNF-α and IL-6 mRNA expression and protein secretion

4μ8C – 50 mg

Brand:
Cayman
CAS:
14003-96-4
Storage:
-20
UN-No:
Non-Hazardous - /

4µ8C is an inhibitor of inositol requiring enzyme 1 α (IRE1α), which is a protein located in the endoplasmic reticulum (ER) membrane that has kinase and RNase activities triggered by ER stress.{39181} 4µ8C inhibits IRE1α splicing of Xbp1 mRNA (IC50 = 6.8 µM) and reduces subsequent gene expression of Erdj4 (IC50 = 3.4 µM) in stress-cultured MEF cells but does not block IRE1α autophosphorylation. It reduces IL-4 production in CD4+ T cells isolated from murine spleen and LPS-stimulated increases in TNF-α and IL-6 mRNA expression and protein secretion in isolated alveolar macrophages from patients with cystic fibrosis.{39182,39183}  

 

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Description

An IRE1α inhibitor; inhibits IRE1α splicing of Xbp1 mRNA (IC50 = 6.8 µM); reduces Erdj4 gene expression downstream of IRE1α and Xbp1 (IC50 = 3.4 µM); does not block IRE1α autophosphorylation; reduces IL-4 production in CD4+ T cells; reduces LPS-stimulated increases in TNF-α and IL-6 mRNA expression and protein secretion ,

Formal name: 7-hydroxy-4-methyl-2-oxo-2H-1-benzopyran-8-carboxaldehyde

Synonyms:  IRE1 Inhibitor III

Molecular weight: 204.2

CAS: 14003-96-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cell Biology|Endomembrane System & Vesicular Trafficking||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Immunology & Inflammation|Innate Immunity

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