A withanolide steroidal lactone with anti-inflammatory and anticancer activities; inhibits LPS-induced NO production in RAW 264.7 cells and TNF-α-induced NF-κB activity in HEK293 cells (IC50s = 0.32 and 0.04 μM

4β-Hydroxywithanolide E – 1 mg

Brand:
Cayman
CAS:
54334-04-2
Storage:
-20
UN-No:
Non-Hazardous - /

4β-Hydroxywithanolide E is a withanolide steroidal lactone that has been found in P. peruviana and has anti-inflammatory and anticancer activities.{47526,47527,47528} It inhibits LPS-induced nitric oxide (NO) production in RAW 264.7 cells and TNF-α-induced NF-κB activity in HEK293 cells (IC50s = 0.32 and 0.04 μM, respectively).{47526} 4β-Hydroxywithanolide E (5 μM) inhibits LPS-induced increases in inducible nitric oxide synthase (iNOS) and COX-2 levels and Akt and STAT1 phosphorylation in RAW 264.7 cells.{47527} It inhibits Wnt signaling in HCT116 and SW480 colorectal cancer cells (IC50s = 1.85 and 2.67 μM, respectively).{47528} 4β-Hydroxywithanolide E inhibits the proliferation of HCT116, SW480, HT-29, and LoVo cells (IC50s = 0.24-0.51 μM). It halts the cell cycle at the G0/G1 phase in HCT116 and HT-29 cells and induces apoptosis in HCT116 and SW480 cells in a concentration-dependent manner. 4β-Hydroxywithanolide E (10 mg/kg per day for 14 days) reduces tumor growth in an HCT116 mouse xenograft model.  

 

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SKU: 27245 - 1 mg Category:

Description

A withanolide steroidal lactone with anti-inflammatory and anticancer activities; inhibits LPS-induced NO production in RAW 264.7 cells and TNF-α-induced NF-κB activity in HEK293 cells (IC50s = 0.32 and 0.04 μM, respectively); inhibits LPS-induced increases in iNOS and COX-2 levels and Akt and STAT1 phosphorylation in RAW 264.7 cells at 5 μM; inhibits Wnt signaling in HCT116 and SW480 colorectal cancer cells (IC50s = 1.85 and 2.67 μM, respectively); inhibits the proliferation of HCT116, SW480, HT-29, and LoVo cells (IC50s = 0.24-0.51 μM); halts the cell cycle at the G0/G1 phase in HCT116 and HT-29 cells and induces apoptosis in HCT116 and SW480 cells; reduces tumor growth in an HCT116 mouse xenograft model at 10 mg/kg per day for 14 days

Formal name: 5β,6β-epoxy-4β,14,17α,20,22R-pentahydroxy-1-oxo-ergosta-2,24-dien-26-oic acid, ẟ-lactone

Synonyms:  NSC 212509

Molecular weight: 502.6

CAS: 54334-04-2

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products||Research Area|Cancer|Cell Cycle|G1||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|Wnt Signaling||Research Area|Immunology & Inflammation|Innate Immunity

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