An oxysterol; a major oxysterol cholesterol metabolite and a precursor in the synthesis of bile acids; formed from cholesterol by CYP3A4 and CYP3A5; has an unusually long half-life in plasma

4β-hydroxy Cholesterol – 25 mg

Brand:
Cayman
CAS:
17320-10-4
Storage:
-20
UN-No:
Non-Hazardous - /

4β-hydroxy Cholesterol is a major oxysterol cholesterol metabolite and a precursor in the synthesis of bile acids that is found in human circulation.{31450} It is formed from cholesterol by the cytochrome P450 (CYP) isoforms CYP3A4 and CYP3A5.{31450} 4β-hydroxy Cholesterol has an unusually long half-life in plasma (~60 hours) as a result of slow elimination, particularly due to a slow rate of 7α-hydroxylation, which is the rate-limiting step for further conversion into bile acids.  

 

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Description

An oxysterol; a major oxysterol cholesterol metabolite and a precursor in the synthesis of bile acids; formed from cholesterol by CYP3A4 and CYP3A5; has an unusually long half-life in plasma

Formal name: cholest-5-ene-3β,4β-diol

Synonyms: 

Molecular weight: 402.7

CAS: 17320-10-4

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Sterol Lipids||Research Area|Endocrinology & Metabolism|Bile Acids & Microbiome||Research Area|Lipid Biochemistry|Cytochrome P450 Pathways||Research Area|Lipid Biochemistry|Sterol Lipids||Research Area|Toxicology|Drug Metabolism|Cytochrome P450||Research Area|Toxicology|Drug Metabolism|Drug Metabolites

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