An active metabolite of cholesterol; formed when cholesterol is metabolized by CYP27A1; decreases Aβ42 (EC50 = 250 nM) and increases Aβ38 levels with no effect on total Aβ in CHO2B7 cells; decreases endogenous murine Aβ42 production (60% and 75% decrease at concentrations of 3 and 10 μM

3β-hydroxy-5-Cholestenoic Acid – 1 mg

Brand:
Cayman
CAS:
6561-58-6
Storage:
-20
UN-No:
Non-Hazardous - /

3β-hydroxy-5-Cholestenoic acid is an active metabolite of cholesterol formed when cholesterol is metabolized by the cytochrome P450 (CYP) isomer CYP27A1.{41086} 3β-hydroxy-5-Cholestenoic acid is a modulator of γ-secretase that decreases amyloid β (1-42) peptide (Aβ42; EC50 = 250 nM) and increases Aβ38 levels with no effect on total Aβ in CHO2B7 cells. It decreases endogenous murine Aβ42 production by 60 and 75% in mouse postnatal neuron-glia cultures at concentrations of 3 and 10 μM, respectively.  

 

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Description

An active metabolite of cholesterol; formed when cholesterol is metabolized by CYP27A1; decreases Aβ42 (EC50 = 250 nM) and increases Aβ38 levels with no effect on total Aβ in CHO2B7 cells; decreases endogenous murine Aβ42 production (60% and 75% decrease at concentrations of 3 and 10 μM, respectively)

Formal name: (3β)-3-hydroxy-cholest-5-en-26-oic acid

Synonyms:  3β-hydroxy-5-CA|Cholesterol-26-carboxylic Acid

Molecular weight: 416.6

CAS: 6561-58-6

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Lipids|Sterol Lipids||Product Type|Biochemicals|Small Molecule Inhibitors|Peptidases & Proteases||Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Lipid Biochemistry|Cytochrome P450 Pathways||Research Area|Lipid Biochemistry|Sterol Lipids||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease||Research Area|Toxicology|Drug Metabolism|Cytochrome P450||Research Area|Toxicology|Drug Metabolism|Drug Metabolites

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