An active quinidine metabolite; prolongs repolarization of canine Purkinje fibers in vitro; prevents ventricular fibrillation and ventricular tachycardia after coronary reperfusion in isolated rat hearts in a dose-dependent manner

(3S)-hydroxy Quinidine – 1 mg

Brand:
Cayman
CAS:
53467-23-5
Storage:
4
UN-No:
Non-Hazardous - /

(3S)-hydroxy Quinidine is an active quinidine metabolite.{38062} Quinidine, an antiarrhythmic agent, undergoes rapid first-pass metabolism by the cytochrome P450 (CYP) isoforms CYP3A4, CYP2C9, CYP2E1, and CYP3A5, with CYP3A4 being the most active enzyme in the (3S)-hydroxy quinidine formation. (3S)-hydroxy Quinidine prolongs repolarization of canine Purkinje fibers in vitro and prevents ventricular fibrillation and ventricular tachycardia after coronary reperfusion in isolated rat hearts in a dose-dependent manner.{36200,36201}  

 

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SKU: 23411 - 1 mg Category:

Description

An active quinidine metabolite; prolongs repolarization of canine Purkinje fibers in vitro; prevents ventricular fibrillation and ventricular tachycardia after coronary reperfusion in isolated rat hearts in a dose-dependent manner

Formal name: 6′-methoxy-cinchonan-3,9S-diol

Synonyms: 

Molecular weight: 340.4

CAS: 53467-23-5

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Product Type|Biochemicals|Small Molecule Inhibitors||Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Cardiovascular System|Cardiovascular Diseases|Myocardial Infarction||Research Area|Cardiovascular System|Heart|Arrhythmia||Research Area|Toxicology|Drug Metabolism|Cytochrome P450||Research Area|Toxicology|Drug Metabolism|Drug Metabolites

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