An inotropic thyroid hormone analogue of L-thyroxine; binds to TRα and TRβ (Kas = 2.4 and 4.06 x 107 M-1

3,5-Diiodothyropropionic Acid – 25 mg

Brand:
Cayman
CAS:
1158-10-7
Storage:
-20
UN-No:
Non-Hazardous - /

3,5-Diiodothyropropionic acid (DITPA) is an inotropic thyroid hormone analogue of L-thyroxine (Item No. 14116) that binds to the thyroid hormone receptors TRα and TRβ (Kas = 2.4 and 4.06 x 107 M-1, respectively, for human recombinant receptors).{40907} DITPA increases mRNA expression of α-myosin heavy chain (α-MHC) in primary rat cardiomyocytes (EC50 = ~0.5 μM). Ex vivo, DITPA prevents myocardial infarction-induced loss of contractility in rabbit cardiomyocytes when administered at a dose of 3.75 mg/kg per day.{40908} DITPA (3.75 mg/kg per day) increases expression of VEGF, basic fibroblast growth factor (bFGF), angiopoietin-1, and angiopoietin-1 receptor (Tie-2) as well as angiogenesis in non-infarcted cardiac tissue in rats.{40909} It also decreases infarct size expansion, stimulates arteriolar growth, and inhibits ventricular remodeling post-myocardial infarction in rats when administered at a dose of 3.5 mg/kg per day.{40910}  

 

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SKU: 23299 - 25 mg Category:

Description

An inotropic thyroid hormone analogue of L-thyroxine; binds to TRα and TRβ (Kas = 2.4 and 4.06 x 107 M-1, respectively, for human recombinant receptors); increases mRNA expression of α-MHC in primary rat cardiomyocytes (EC50 = ~0.5 μM); prevents myocardial infarction-induced loss of contractility ex vivo in rabbit cardiomyocytes (3.75 mg/kg per day); increases expression of VEGF, bFGF, angiopoietin-1, and Tie-2 as well as angiogenesis in non-infarcted cardiac tissue in rats (3.75 mg/kg per day); decreases infarct size expansion, stimulates arteriolar growth, and inhibits ventricular remodeling post-myocardial infarction in rats (3.5 mg/kg per day)

Formal name: 4-(4-hydroxyphenoxy)-3,5-diiodo-benzenepropanoic acid

Synonyms:  DITPA

Molecular weight: 510.1

CAS: 1158-10-7

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Receptor Pharmacology||Research Area|Cardiovascular System|Cardiovascular Diseases|Myocardial Infarction||Research Area|Cardiovascular System|Heart|Myocardial Contractility||Research Area|Cardiovascular System|Vasculature|Angiogenesis||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Thyroid Hormones

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