Description
A natural phenolic compound that has antioxidant, anti-inflammatory, and antiviral biological activities; scavenges DPPH radicals in a cell-free assay (IC50 = 71.8 μM); inhibits superoxide production in fMLF- and cytochalasin B-activated human neutrophils (IC50 = 1.92 μM); inhibits HIV-1 integrase 3’-end processing, strand transfer, and disintegration in a cell-free assay (IC50s = 0.33, 0.34, and 0.66 μg/ml, respectively); inhibits HIV-1-induced cytotoxicity in MT-2 cells (ED50 = 1 μg/ml); protects mice from LPS-induced acute lung injury and decreases neutrophil count in BALF at 25 mg/kg
Formal name: (1α,3R,4α,5R)-3,5-bis[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]-1,4-dihydroxy-cyclohexanecarboxylic acid
Synonyms: 3,5-DCQA|Isochlorogenic Acid A
Molecular weight: 516.5
CAS: 2450-53-5
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Antivirals|Integrase Inhibitors||Product Type|Biochemicals|Natural Products|Polyphenols||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Infectious Disease|Viral Diseases|HIV & AIDS||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Non-enzymatic
