A dopamine metabolite; levels are increased 5- to 6-fold compared to wild-type in the nucleus accumbens

3,4-Dihydroxyphenylacetic Acid – 25 g

Brand:
Cayman
CAS:
102-32-9
Storage:
-20
UN-No:
Non-Hazardous - /

3,4-dihydroxyphenylacetic acid (DOPAC) is a metabolite of dopamine (Item No. 21992) formed through deamination by monoamine oxidase (MAO).{36669} DOPAC is further metabolized by catechol-O-methyltransferase (COMT) to form homovanillic acid, and DOPAC levels are increased 5- to 6-fold compared to wild-type in the nucleus accumbens, striatum, and prefrontal cortex of COMT knockout mice. DOPAC oxidation is catalyzed by α-synuclein and oxidized DOPAC binds to monomeric α-synuclein preventing fibrillation.{36668} In vivo, foot shock stress increases DOPAC levels relative to control by approximately 45% in the prefrontal cortex and by 15% in the olfactory tubercles and ventral tegmental area (VTA) in rats.{36667}  

 

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SKU: 24912 - 25 g Category:

Description

A dopamine metabolite; levels are increased 5- to 6-fold compared to wild-type in the nucleus accumbens, striatum, and prefrontal cortex of COMT knockout mice; oxidized DOPAC binds to monomeric α-synuclein, preventing fibrillation; foot shock stress increases levels relative to control in the prefrontal cortex, olfactory tubercles, and VTA in rats

Formal name: 3,4-dihydroxy-benzeneacetic acid

Synonyms:  DOPAC|NSC 73191

Molecular weight: 168.1

CAS: 102-32-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease

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