A polyphenol with diverse biological activities; active against MRSA at 0.01 µg/ml; prevents hexavalent chromium-induced formation of ROS and NOS in a concentration-dependent manner and increases GSH in isolated human erythrocytes; selectively inhibits human DNA topoisomerase II (IC50 = 150 µM) over human topoisomerase I and a variety of mammalian polymerases (IC50s = >200 µM); inhibits proliferation of HT-29 cells at 362 µM but not HCT116 cells at 100 µM

3,4-Dihydroxybenzaldehyde – 10 g

Brand:
Cayman
CAS:
139-85-5
Storage:
-20
UN-No:
Non-Hazardous - /

3,4-Dihydroxybenzaldehyde is a polyphenol that has been found in S. miltiorrhiza and has diverse biological activities, including antibacterial, antioxidative, and anticancer properties.{45267,45268,45269,45270} It is active against methicillin-resistant S. aureus (MRSA) when used at a concentration of 0.01 µg/ml.{45268} It prevents hexavalent chromium-induced formation of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in a concentration-dependent manner and increases glutathione (GSH) levels in isolated human erythrocytes.{45267} 3,4-Dihydroxybenzaldehyde selectively inhibits human DNA topoisomerase II (IC50 = 150 µM) over human topoisomerase I and a variety of mammalian polymerases (IC50s = >200 µM).{45269} It inhibits proliferation of HT-29 cells when used at a concentration of 362 µM but not HCT116 cells at a concentration of 100 µM.{45270,45269}  

 

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SKU: 27547 - 10 g Category:

Description

A polyphenol with diverse biological activities; active against MRSA at 0.01 µg/ml; prevents hexavalent chromium-induced formation of ROS and NOS in a concentration-dependent manner and increases GSH in isolated human erythrocytes; selectively inhibits human DNA topoisomerase II (IC50 = 150 µM) over human topoisomerase I and a variety of mammalian polymerases (IC50s = >200 µM); inhibits proliferation of HT-29 cells at 362 µM but not HCT116 cells at 100 µM

Formal name: 3,4-dihydroxy-benzaldehyde

Synonyms:  NSC 22961|Protocatechualdehyde|Protocatechuic aldehyde

Molecular weight: 138.1

CAS: 139-85-5

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Natural Products|Polyphenols||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Product Type|Biochemicals|Small Molecule Inhibitors|Topoisomerases||Research Area|Cancer|DNA Damage and Repair|Topoisomerase||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases|MRSA||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Nitrogen||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen||Research Area|Oxidative Stress & Reactive Species|Reactive Sulfur|Glutathione

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