A thyroid hormone; agonist of TRα and TRβ (Kis = 2.3 nM for both); modulates diverse biological properties

3,3′,5-Triiodo-L-thyronine (sodium salt) – 500 mg

Brand:
Cayman
CAS:
55-06-1
Storage:
-20
UN-No:
Non-Hazardous - /

3,3′,5-Triiodo-L-thyronine (T3) is a thyroid hormone.{61095} It is produced by 5′-monodeiodination of the prohormone thyroxine (T4) in various tissues, including liver and kidney. T3 is an agonist of thyroid hormone receptors TRα and TRβ (Kis = 2.3 nM for both) that modulates diverse biological properties, including metabolism, cardiac function, growth, and redox signaling.{27008,27007,27010,27009} It also functions as an inhibitor of L-type amino acid transporter 1 (LAT1), inhibiting LAT1-mediated leucine uptake in HEK293 cells when used at a concentration of 10 µM.{59277}  

 

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Description

A thyroid hormone; agonist of TRα and TRβ (Kis = 2.3 nM for both); modulates diverse biological properties, including metabolism, cardiac function, growth, and redox signaling; inhibits LAT1-mediate leucine uptake in HEK293 cells at 10 µM

Formal name: O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine, monosodium salt

Synonyms:  ​​L-3,3′,5-Triiodothyronine|Liothyronine|T3

Molecular weight: 672.3

CAS: 55-06-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Cardiovascular System|Heart||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Thyroid Hormones||Research Area|Oxidative Stress & Reactive Species

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