An irreversible inhibitor of mitochondrial Complex II succinate dehydrogenase

3-Nitropropionic Acid – 1 g

Brand:
Cayman
CAS:
504-88-1
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

3-Nitropropionic acid (3-NP) is an irreversible inhibitor of mitochondrial respiratory Complex II succinate dehydrogenase, resulting in energy depletion through disruption of the electron transport chain.{29416,29417,29415} This compound is a natural toxin of certain plants and fungi. Administration of 3-NP to rats (12 mg/kg per day) produces progressive striatal degeneration, while lower doses (8 mg/kg daily) in nonhuman primates results in neuropathologic and clinical features of Huntington’s disease.{29416} Conversely, Huntington’s disease results in a loss of Complex II activity.{29417} 3-NP also induces convulsions and is used to examine interventions effective in a mouse model of epilepsy.{29418}  

 

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Description

An irreversible inhibitor of mitochondrial Complex II succinate dehydrogenase, resulting in energy depletion through disruption of the electron transport chain; used in animal models of Huntington’s disease and epilepsy

Formal name: 3-nitro-propanoic acid

Synonyms:  3-NP|NSC 64266|β-Nitropropionic Acid

Molecular weight: 119.1

CAS: 504-88-1

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Product Type|Biochemicals|Small Molecule Inhibitors|Oxidative Phosphorylation||Product Type|Biochemicals|Toxins||Research Area|Cell Biology|Mitochondrial Biology||Research Area|Neuroscience|Neurodegenerative Disorders|Huntington’s Disease||Research Area|Neuroscience|Seizure Disorders||Research Area|Plant Biology||Research Area|Toxicology|Environmental

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