An intermediate in the metabolism of valine; increases fatty acid uptake by HUVECs at 0.1-100 mM; increases fatty acid uptake and lipid accumulation in mouse skeletal muscle; levels are increased in db/db diabetic mice and in humans with diabetes; human plasma levels are increased in obesity and correlate with a future risk of type 2 diabetes; human serum levels decrease following an exercise regimen of 2.5 hours of running for three days

3-Hydroxyisobutyrate (sodium salt) – 250 mg

Brand:
Cayman
CAS:
1219589-99-7
Storage:
-20
UN-No:
Non-Hazardous - /

3-Hydroxyisobutyrate (3-HIB) is an intermediate in the metabolism of the branched-chain amino acid valine that is secreted by skeletal muscle.{45049,43558} It dose-dependently increases fatty acid uptake by human umbilical vein endothelial cells (HUVECs) when used at concentrations ranging from 0.1 to 100 mM.{43558} 3-HIB also increases fatty acid uptake and lipid accumulation in mouse skeletal muscle when administered in drinking water. The levels of 3-HIB in muscle are increased in db/db diabetic mice and in humans with diabetes. Human plasma levels are increased in obesity and correlate with a future risk of type 2 diabetes.{43559} In addition, human serum levels of 3-HIB decrease by 2.5-fold immediately following an exercise regimen of 2.5 hours of running for three days.{45049}  

 

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SKU: 26105 - 250 mg Category:

Description

An intermediate in the metabolism of valine; increases fatty acid uptake by HUVECs at 0.1-100 mM; increases fatty acid uptake and lipid accumulation in mouse skeletal muscle; levels are increased in db/db diabetic mice and in humans with diabetes; human plasma levels are increased in obesity and correlate with a future risk of type 2 diabetes; human serum levels decrease following an exercise regimen of 2.5 hours of running for three days

Formal name: 3-hydroxy-2-methyl-propanoic acid, monosodium salt

Synonyms:  3-HIB

Molecular weight: 126.1

CAS: 1219589-99-7

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Obesity

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