Found in the lipid A part of LPS and useful as chemical marker of endotoxins; accumulates during long-chain 3-hydroxy-acyl-CoA dehydrogenase and mitochondrial trifunctional protein deficiencies

3-hydroxy Palmitic Acid – 1 g

Brand:
Cayman
CAS:
2398-34-7
Storage:
-20
UN-No:
Non-Hazardous - /

3-hydroxy Palmitic acid is a form of the 16:0 lipid palmitic acid (Item No. 10006627). The lipid A part of lipopolysaccharides contain various 3-hydroxy fatty acids, making oxylipins such as 3-hydroxy palmitic acid useful as chemical markers of endotoxins.{31684} In R. solanacearum, 3-hydroxy palmitic acid is converted by an S-adenosyl methionine-dependent methyltransferase to 3-hydroxy palmitic acid methyl ester, which acts as a quorum sensing signal molecule for post-transcriptional modulation of genes involved in virulence.{31682} Long-chain 3-hydroxy fatty acids, such as 3-hydroxy palmitic acid, are also known to accumulate during long-chain 3-hydroxy-acyl-CoA dehydrogenase and mitochondrial trifunctional protein deficiencies.{31683} Such accumulation induces oxidative stress, leading to mitochondrial bioenergetics deregulation and eventual multi-organ dysfunction.{31683}  

 

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Description

Found in the lipid A part of LPS and useful as chemical marker of endotoxins; accumulates during long-chain 3-hydroxy-acyl-CoA dehydrogenase and mitochondrial trifunctional protein deficiencies, inducing oxidative stress and leading to mitochondrial bioenergetics deregulation and eventual multi-organ dysfunction

Formal name: 3-hydroxy-hexadecanoic acid

Synonyms:  DL-3-hydroxy Palmitic Acid|β-hydroxy Hexadecanoic Acid|β-hydroxy Palmitic Acid

Molecular weight: 272.4

CAS: 2398-34-7

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Fatty Acids||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Fungal Diseases||Research Area|Infectious Disease|Quorum Sensing||Research Area|Lipid Biochemistry||Research Area|Toxicology

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