A creatine analog that alters skeletal muscle energy expenditure; reduces cellular ATP

3-Guanidinopropionic Acid – 10 g

Brand:
Cayman
CAS:
353-09-3
Storage:
-20
UN-No:
Non-Hazardous - /

3-Guanidinopropionic acid is a creatine analog that alters skeletal muscle energy expenditure. It reduces cellular ATP, creatine, and phosphocreatine levels and stimulates AMP-activated protein kinase (AMPK), activating PPARγ coactivator 1α (PGC-1α).{27453,27454,27456,27452} PGC-1α activation results in enhanced expression of AMPK, as well as genes for oxidative phosphorylation, electron transport chain, and mitochondrial biogenesis, increasing oxidative muscle fibers, numbers of mitochondria, and motor performance.{27453,27455} 3-Guanidinopropionic acid evokes a shift from glycolytic to oxidative metabolism, increased cellular glucose uptake, and increased fatigue tolerance.{27454} In aged rats, reduced mitochondrial biogenesis in response to chronic activation of AMPK with 3-guanidinopropionic acid leads to metabolic insufficiency that can contribute to muscle loss.{27457,27455}  

 

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Description

A creatine analog that alters skeletal muscle energy expenditure; reduces cellular ATP, creatine, and phosphocreatine levels and stimulates AMPK, activating PGC-1α; increases the expression of genes for oxidative phosphorylation, electron transport chain, and mitochondrial biogenesis

Formal name: N-(aminoiminomethyl)-β-alanine

Synonyms:  PNU 10483|β-GPA

Molecular weight: 131.1

CAS: 353-09-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Activators|Kinases||Research Area|Cell Biology|Mitochondrial Biology||Research Area|Endocrinology & Metabolism|Nutrient Sensing

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