A fluorogenic CYP450 substrate; a substrate for CYP1A1 and CYP1A2; metabolized to a lesser extent by CYP2D6 and CYP2C19; metabolized to 3-cyano-7-hydroxycoumarin and its fluorescence can be used to quantify CYP450 isoform activity

3-Cyano-7-ethoxycoumarin – 50 mg

Brand:
Cayman
CAS:
117620-77-6
Storage:
-20
UN-No:
Non-Hazardous - /

3-Cyano-7-ethoxycoumarin is a fluorogenic probe that acts as a substrate for the cytochrome P450 (CYP) isoforms CYP1A1 and CYP1A2 and is metabolized to a lesser extent by CYP2D6 and CYP2C19.{27560,42278} It is metabolized to 3-cyano-7-hydroxycoumarin, which displays excitation/emission maxima of 408/450 nm, respectively.{42279} 3-Cyano-7-ethoxycoumarin has also been used to quantify mixed function oxidase activity.  

 

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SKU: 25441 - 50 mg Category:

Description

A fluorogenic CYP450 substrate; a substrate for CYP1A1 and CYP1A2; metabolized to a lesser extent by CYP2D6 and CYP2C19; metabolized to 3-cyano-7-hydroxycoumarin and its fluorescence can be used to quantify CYP450 isoform activity

Formal name: 7-ethoxy-2-oxo-2H-1-benzopyran-3-carbonitrile

Synonyms: 

Molecular weight: 215.2

CAS: 117620-77-6

Purity: ≥95%

Formulation: A crystalline solid

Application|Enzyme Activity||Application|Fluorescence||Product Type|Biochemicals|Labeling & Detection|Enzyme Substrates||Product Type|Biochemicals|Labeling & Detection|Fluorescent Probes||Research Area|Toxicology|Drug Metabolism|Cytochrome P450

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