An alkylating agent and antimetabolite of pyruvate; decreases proliferation of BEL-7402 cells expressing hexokinase II; reduces tumor growth and induces tumor necrosis in a hepatocellular carcinoma mouse xenograft model at 50 mg/kg per day

3-Bromopyruvic Acid – 1 g

Brand:
Cayman
CAS:
1113-59-3
Storage:
-20
UN-No:
De Minimis - 3261 / 8

3-Bromopyruvic Acid (3-BP) is an alkylating agent and an antimetabolite of pyruvate that is metabolized through glutathione conjugation.{34038,34035} It decreases proliferation of hepatocellular carcinoma BEL-7402 cells that express hexokinase II, an isoform of hexokinase overexpressed in many cancers.{43142,34037} 3-BP reduces tumor growth and induces tumor necrosis in a hepatocellular carcinoma mouse xenograft model when administered at a dose of 50 mg/kg per day, six days per week, for three weeks.{43142}  

 

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Description

An alkylating agent and antimetabolite of pyruvate; decreases proliferation of BEL-7402 cells expressing hexokinase II; reduces tumor growth and induces tumor necrosis in a hepatocellular carcinoma mouse xenograft model at 50 mg/kg per day, six days per week, for three weeks

Formal name: 3-bromo-2-oxo-propanoic acid

Synonyms:  3-BP|NSC 11731|NSC 62343|β-Bromopyruvic acid

Molecular weight: 167

CAS: 1113-59-3

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|DNA Alkylating Agents||Research Area|Cancer|Cell Death|Necrosis||Research Area|Endocrinology & Metabolism|Carbohydrate Metabolism

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