An internal standard for the quantification of 25-hydroxy cholesterol by GC- or LC-MS

25-hydroxy Cholesterol-d6 – 500 µg

Brand:
Cayman
CAS:
88247-69-2
Storage:
-20
UN-No:
Non-Hazardous - /

25-hydroxy Cholesterol contains six deuterium atoms at the 26, 26, 26, 27, 27, and 27 positions. It is intended for use as an internal standard for the quantification of 25-hydroxy cholesterol by GC- or LC-mass spectrometry. 25-hydroxy Cholesterol is a side-chain substituted oxysterol derived from dietary cholesterol that inhibits the cleavage of sterol regulatory element binding proteins (SREBPs) to suppress endogenous cholesterol synthesis in various cell types.{20437} It has been implicated in a variety of metabolic events including cholesterol homeostasis and atherosclerosis as well as antitumor activities as it has been shown to induce apoptosis through down-regulation of Bcl-2 expression and activation of caspases.{20436} Immunomodulating capabilities have also been observed as the oxysterol can act as a LXR-RXR ligand coupling cholesterol synthesis to T cell proliferation, can reduce (EC50 ~ 65 nM) IgA production by B cells in response to IL-2, and can suppress differentiation of monocytes into macrophages.{20444,20445,20446}  

 

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SKU: 11099 - 500 µg Category:

Description

An internal standard for the quantification of 25-hydroxy cholesterol by GC- or LC-MS

Formal name: cholest-5-ene-26,26,26,27,27,27-d6-3β,25-diol

Synonyms: 

Molecular weight: 408.7

CAS: 88247-69-2

Purity: ≥99% deuterated forms (d1-d6)

Formulation: A crystalline solid

Application|Mass Spectrometry||Product Type|Biochemicals|Analytical Standards||Product Type|Biochemicals|Isotopically Labeled Standards|Deuterium||Product Type|Biochemicals|Lipids|Sterol Lipids||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cardiovascular System|Cardiovascular Diseases|Atherosclerosis||Research Area|Cardiovascular System|Lipids & Lipoproteins|Cholesterol Metabolism||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Lipid Biochemistry|Sterol Lipids

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