An inhibitor of 5-LO (IC50 = 0.33 µM for thapsigargin-stimulated 5-LO product synthesis); scavenges DPPH radicals (IC50 = 16.41 µM) in a cell-free assay; decreases viability of RCC4 and 786-O cells lacking VHL (IC50s = 8 and 34.8 µM

2,5-Dihydroxycinnamic Acid phenethyl ester – 10 mg

Brand:
Cayman
CAS:
179691-97-5
Storage:
-20
UN-No:
Non-Hazardous - /

2,5-Dihydroxycinnamic acid phenethyl ester is an inhibitor of 5-lipoxygenase (5-LO) with an IC50 value of 0.33 µM for inhibition of 5-LO product synthesis in polymorphonuclear leukocytes (PMNLs) stimulated with the sarcoendoplasmic reticulum calcium ATPase (SERCA) inhibitor thapsigargin (Item No. 10522).{50734} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals (IC50 = 16.41 µM) in a cell-free assay. 2,5-Dihydroxycinnamic acid phenethyl ester selectively decreases viability of RCC4 and 786-O cells lacking the Von Hippel-Lindau (VHL) tumor suppressor gene (IC50s = 8 and 34.8 µM, respectively) over cells homozygously expressing VHL (IC50s = 99.6 and >100 µM, respectively). However, it also decreases viability of RCC10 VHL-/- and RCC10 VHL+/+ cells (IC50s = 5.04 and 0.96 µM, respectively). It increases the levels of pro-caspase-3a, LC3B-I, and LC3B-II in RCC4 VHL-/- cells in a concentration-dependent manner.  

 

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Description

An inhibitor of 5-LO (IC50 = 0.33 µM for thapsigargin-stimulated 5-LO product synthesis); scavenges DPPH radicals (IC50 = 16.41 µM) in a cell-free assay; decreases viability of RCC4 and 786-O cells lacking VHL (IC50s = 8 and 34.8 µM, respectively) over cells homozygously expressing VHL (IC50s = 99.6 and >100 µM, respectively); decreases viability of RCC10 VHL-/- and RCC10 VHL+/+ cells (IC50s = 5.04 and 0.96 µM, respectively)

Formal name: (2E)-3-(2,5-dihydroxyphenyl)-2-propenoic acid, 2-phenylethyl ester

Synonyms: 

Molecular weight: 284.3

CAS: 179691-97-5

Purity: ≥98%

Formulation: A crystalline solid

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