An oxysterol; activates LXRs in the developing ventral midbrain to induce stem cell differentiation into dopaminergic neurons; inhibits IL-6 production and degranulation of bone marrow-derived murine mast cells that express LXRβ; inhibits the conversion of demosterol to cholesterol by DHCR24/Seladin-1 in CHO-7 and SRD-1 cells at 2.5 μM

24(S),25-epoxy Cholesterol – 1 mg

Brand:
Cayman
CAS:
77058-74-3
Storage:
-20
UN-No:
Non-Hazardous - /

24(S),25-epoxy Cholesterol is an oxysterol and the most abundant oxysterol in mouse ventral midbrain.{43943} It activates liver X receptors (LXRs) in the developing ventral midbrain to induce stem cell differentiation into dopaminergic neurons. 24(S),25-epoxy Cholesterol inhibits IL-6 production and degranulation of bone marrow-derived murine mast cells that express LXRβ.{43945} It inhibits the conversion of desmosterol to cholesterol by 3β-hydroxysterol Δ24-reductase (DHCR24/Seladin-1) in CHO-7 and SRD-1 cells when used at a concentration of 2.5 μM.{43944}  

 

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SKU: 10131 - 1 mg Category:

Description

An oxysterol; activates LXRs in the developing ventral midbrain to induce stem cell differentiation into dopaminergic neurons; inhibits IL-6 production and degranulation of bone marrow-derived murine mast cells that express LXRβ; inhibits the conversion of demosterol to cholesterol by DHCR24/Seladin-1 in CHO-7 and SRD-1 cells at 2.5 μM

Formal name: (3β,24S)-24,25-epoxy-cholest-5-en-3-ol

Synonyms:  24(S)-24,25-EC

Molecular weight: 400.6

CAS: 77058-74-3

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Lipids|Sterol Lipids||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cell Biology|Stem Cell Research|Differentiation||Research Area|Endocrinology & Metabolism|Hormones & Receptors|FXRs & LXRs||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Neuroscience

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