An immediate precursor to cholesterol in the Bloch pathway of cholesterol biosynthesis; reported to activate liver X receptor-target genes in both the liver of cholesterol-free mice and in cholesterol-starved macrophage foam cells in atherosclerotic lesions

24-dehydro Cholesterol – 25 mg

Brand:
Cayman
CAS:
313-04-2
Storage:
-20
UN-No:
Non-Hazardous - /

24-dehydro Cholesterol is an immediate precursor to cholesterol in the Bloch pathway of cholesterol biosynthesis. Structurally, it varies from cholesterol only by a single double bond at carbon 24 and has been used as cholesterol substitute in cellular membrane studies.{26099} During brain development, 24-dehydro cholesterol transiently accumulates, composing up to 30% of total brain sterol, where it is poised to rapidly enrich membrane sterols.{26098} However, defects in cholesterol synthesis can lead to a condition called, desmosterolosis, which results in an accumulation of excess 24-dehydro cholesterol.{26100} 24-dehydro Cholesterol has been reported to activate liver X receptor-target genes in both the liver of cholesterol-free mice and in cholesterol-starved macrophage foam cells in atherosclerotic lesions.{26096,26097}  

 

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Description

An immediate precursor to cholesterol in the Bloch pathway of cholesterol biosynthesis; reported to activate liver X receptor-target genes in both the liver of cholesterol-free mice and in cholesterol-starved macrophage foam cells in atherosclerotic lesions

Formal name: (3β)-cholesta-5,24-dien-3-ol

Synonyms:  Desmosterol|NSC 226126

Molecular weight: 384.6

CAS: 313-04-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Sterol Lipids||Research Area|Cardiovascular System|Cardiovascular Diseases|Atherosclerosis||Research Area|Cardiovascular System|Lipids & Lipoproteins|Cholesterol Metabolism||Research Area|Endocrinology & Metabolism|Inborn Errors of Metabolism||Research Area|Lipid Biochemistry|Sterol Lipids||Research Area|Neuroscience

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