An alkaloid; reduces kainate-induced production of ROS and cytotoxicity in primary rat hippocampal neurons at 5 µM; induces vasodilation in precontracted isolated and endothelium-denuded rat tail artery strips and reduces blood pressure in anesthetized rats at 0.1 mM; decreases infarct volume

2,3,5,6-Tetramethylpyrazine – 50 g

Brand:
Cayman
CAS:
1124-11-4
Storage:
-20
UN-No:
Non-Hazardous - /

2,3,5,6-Tetramethylpyrazine is an alkaloid that has been found in L. wallichii and has diverse biological activities.{54098,54099,54100} It reduces kainate-induced increases in production of reactive oxygen species (ROS) and cytotoxicity in primary rat hippocampal neurons when used at a concentration of 5 µM.{54098} 2,3,5,6-Tetramethylpyrazine (0.1 mM) induces vasodilation in precontracted isolated and endothelium-denuded rat tail artery strips and reduces blood pressure in anesthetized rats.{54099} It decreases infarct volume, caspase-3 activation, and hypoxia-inducible factor-1α (HIF-1α) levels in a rat model of focal cerebral ischemia induced by middle cerebral artery occlusion (MCAO) when administered at a dose of 20 mg/kg.{54100}  

 

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SKU: 30281 - 50 g Category:

Description

An alkaloid; reduces kainate-induced production of ROS and cytotoxicity in primary rat hippocampal neurons at 5 µM; induces vasodilation in precontracted isolated and endothelium-denuded rat tail artery strips and reduces blood pressure in anesthetized rats at 0.1 mM; decreases infarct volume, caspase-3 activation, and HIF-1α levels in a rat model of focal cerebral ischemia induced by MCAO at 20 mg/kg

Formal name:

Synonyms:  Chuanxingzine|NSC 36080|NSC 46451|Tetramethylpyrazine

Molecular weight: 136.2

CAS: 1124-11-4

Purity: ≥98%

Formulation: A solid

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