A triterpenoid with anticancer activity; inhibits proliferation of K562

23-hydroxy Betulinic Acid – 10 mg

Brand:
Cayman
CAS:
85999-40-2
Storage:
-20
UN-No:
Non-Hazardous - /

23-hydroxy Betulinic acid is a triterpenoid that has been found in P. chinensis and has anticancer activity.{42830} It inhibits proliferation of K562, B16, and HeLa cells (IC50s = 39.9, 78.5, and 80 µM, respectively), as well as human umbilical vein endothelial cells (HUVECs; IC50 = 94.8 µM). It halts the cell cycle at the S phase and induces apoptosis in K562 cells in a concentration-dependent manner with a loss of the mitochondrial membrane potential and an increase in Bax and cytochrome C protein levels.  

 

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SKU: 27446 - 10 mg Category:

Description

A triterpenoid with anticancer activity; inhibits proliferation of K562, B16, and HeLa cells (IC50s = 39.9, 78.5, and 80 µM, respectively), as well as HUVECs (IC50 = 94.8 µM); halts the cell cycle at the S phase and induces apoptosis in K562 cells

Formal name: (3β,4α)-3,23-dihydroxy-lup-20(29)-en-28-oic acid

Synonyms:  23-HBA

Molecular weight: 472.7

CAS: 85999-40-2

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Natural Products|Terpenes||Research Area|Cancer|Cell Cycle||Research Area|Cancer|Cell Death|Apoptosis

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