TXB2 is released in substantial quantities from aggregating platelets and metabolized during circulation to 11-dehydro TXB2 and 2

2,3-dinor Thromboxane B1 – 50 µg

Brand:
Cayman
CAS:
196493-76-2
Storage:
-20
UN-No:
De Minimis - 1231 / 3

Thromboxane B2 (TXB2) is released in substantial quantities from aggregating platelets and metabolized during circulation to 11-dehydro TXB2 and 2,3-dinor TXB2.{1410} In rats and rabbits, 2,3-dinor TXB1 has been identified as another urinary metabolite of TXB2.{12600,12599} However in human urine, only trace amounts of 2,3-dinor TXB1 have been identified.{12600} In rats, 2,3-dinor TXB1 is excreted at a much higher rate than 2,3-dinor TXB2 (19.2 ± 4.9 ng/24 hr and 1.6 ± 0.3 ng/24 hr, respectively).{12600} Therefore, urinary 2,3-dinor TXB1 is a suitable marker of thromboxane biosynthesis in rats.  

 

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SKU: 10006330 - 50 µg Category:

Description

TXB2 is released in substantial quantities from aggregating platelets and metabolized during circulation to 11-dehydro TXB2 and 2,3-dinor TXB2.{1410} In rats and rabbits, 2,3-dinor TXB1 has been identified as another urinary metabolite of TXB2.{12600,12599} However in human urine, only trace amounts of 2,3-dinor TXB1 have been identified.{12600} In rats, 2,3-dinor TXB1 is excreted at a much higher rate than 2,3-dinor TXB2 (19.2 ± 4.9 ng/24 hr and 1.6 ± 0.3 ng/24 hr, respectively).{12600} Therefore, urinary 2,3-dinor TXB1 is a suitable marker of thromboxane biosynthesis in rats.

Formal name: 9α,11,15S-trihydroxy-2,3-dinor-thromba-13E-en-1-oic acid

Synonyms:  2,3-dinor TXB1

Molecular weight: 344.4

CAS: 196493-76-2

Purity: ≥98%

Formulation: A solution in methyl acetate

Product Type|Biochemicals|Lipids|Thromboxanes||Research Area|Cardiovascular System|Blood|Coagulation & Hemostasis||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway

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