A metabolite of 8-iso PGF2α in humans and rats; present in normal human urine at concentrations of 200-300 pg/ml

2,3-dinor-8-iso Prostaglandin F2α – 100 µg

Brand:
Cayman
CAS:
221664-05-7
Storage:
-20
UN-No:
De Minimis - 1231 / 3

8-iso Prostaglandin F2α (8-iso PGF2α; 8-isoprostane) is a prostaglandin-like product of non-specific lipid peroxidation.{320} 2,3-dinor-8-iso PGF2α is a metabolite of 8-iso PGF2α in humans and rats.{6907} In these species, exogenously infused 8-iso PGF2α is converted to 2,3-dinor-8-iso PGF1α and (2,3-dinor-8-iso PGF2α.{6907,3026} Rat hepatocytes further metabolize 8-iso PGF2α to another β-oxidation product, 2,3,4,5-tetranor-8-iso PGF2α.{6907} 2,3-dinor-8-iso PGF2α is present in normal human urine at concentrations of 200-300 pg/ml.{6907} Its concentration is increased in conditions of oxidative injury (for example, smoking), and correlates well with that of the parent isoprostane, 8-iso PGF2α.{6907}  

 

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Description

A metabolite of 8-iso PGF2α in humans and rats; present in normal human urine at concentrations of 200-300 pg/ml

Formal name: 9α,11α,15S-trihydroxy-2,3-dinor-(8β)-prosta-5Z,13E-dien-1-oic acid

Synonyms:  2,3-dinor-8-iso PGF2α|2,3-dinor-iPF2α-III

Molecular weight: 326.4

CAS: 221664-05-7

Purity: ≥98%

Formulation: A solution in methyl acetate

Product Type|Biochemicals|Lipids|Isoprostanes||Product Type|Biochemicals|Lipids|Prostaglandins||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway||Research Area|Oxidative Stress & Reactive Species|Lipid Peroxidation

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