An active metabolite of gemcitabine; formed by deamination of gemcitabine by cytidine deaminase in the liver; cytotoxic to HepG2 and A549 cancer cells (IC50s = 3.13 and 3.92 µM

2′,2′-Difluoro-2′-deoxyuridine – 25 mg

Brand:
Cayman
CAS:
114248-23-6
Storage:
-20
UN-No:
Non-Hazardous - /

2′,2′-Difluoro-2′-deoxyuridine is an active metabolite of the anticancer nucleoside analog gemcitabine (Item No. 11690).{52668} It is formed by deamination of gemcitabine by cytidine deaminase in the liver. 2′,2′-Difluoro-2′-deoxyuridine is cytotoxic to HepG2 and A549 cancer cells (IC50s = 3.13 and 3.92 µM, respectively). It enhances radiation-induced cell death of ECV304 and NCI H292 cells when used at concentrations ranging from 10 to 100 µM.{52669}  

 

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SKU: 11689 - 25 mg Category:

Description

An active metabolite of gemcitabine; formed by deamination of gemcitabine by cytidine deaminase in the liver; cytotoxic to HepG2 and A549 cancer cells (IC50s = 3.13 and 3.92 µM, respectively); enhances radiation-induced cell death of ECV304 and NCI H292 cells from 10-100 µM

Formal name: 2′-deoxy-2′,2′-difluoro-uridine

Synonyms:  dFdU

Molecular weight: 264.2

CAS: 114248-23-6

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Nucleotides/Nucleosides||Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Cancer|Cell Death||Research Area|Cancer|DNA Damage and Repair||Research Area|Epigenetics, Transcription, & Translation|Writers|DNA/RNA Methylation||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|HIV & AIDS||Research Area|Toxicology|Drug Metabolism|Drug Metabolites

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