A synthetic dinucleotide containing non-canonical 2'5'-phosphodiester bonds; binds the adapter protein STING (Kd = 287 nM); induces IFN-β production (EC50 = 15.8 nM in L929 cells)

2’2’-cGAMP (sodium salt) – 500 µg

Brand:
Cayman
CAS:
1465774-27-9
Storage:
-20
UN-No:
Non-Hazardous - /

2’2’-cGAMP is a synthetic dinucleotide (CDN) that contains non-canonical 2’5′-phosphodiester bonds.{29220} It binds to the adapter protein stimulator of interferon genes (STING; Item Nos. 22816 | 22815), which is a component of the innate immune response that activates the type I interferon pathway when bound to cyclic dinucleotides. 2’2-cGAMP shows weaker binding to STING than 2’3’-cGAMP (Item No. 19887; Kd = 287 and 3.79 nM, respectively) but binds more strongly than 3’3’-cGAMP (Item No. 17966), cyclic di-GMP (Item No. 17144), or 3’2’-cGAMP, which bind in the micromolar range (Kds = 1.04, 1.21, or 1.61 µM, respectively).{29220} Despite weaker binding, 2’2’-cGAMP induces IFN-β production in the same concentration range as 2’3’-cGAMP (EC50s = 15.8 and 19.4 nM, respectively, in L929 cells).  

 

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Description

A synthetic dinucleotide containing non-canonical 2’5′-phosphodiester bonds; binds the adapter protein STING (Kd = 287 nM); induces IFN-β production (EC50 = 15.8 nM in L929 cells)

Formal name: adenylyl-(2’ → 5’)-2’-guanylic acid, cyclic nucleotide, disodium salt

Synonyms:  2’,2’-Cyclic GMP-AMP|Adenosine-Guanosine 2’,2’-cyclic monophosphate|cGAMP(2’-5’)

Molecular weight: 718.4

CAS: 1465774-27-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Nucleotides/Nucleosides||Research Area|Epigenetics, Transcription, & Translation|RNA, DNA, & Protein Synthesis||Research Area|Immunology & Inflammation|Autoimmunity||Research Area|Immunology & Inflammation|Innate Immunity|Pattern Recognition||Research Area|Immunology & Inflammation|Innate Immunity|STING||Research Area|Infectious Disease

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