An allosteric Smo agonist; activates Hh signaling in a gene transcription reporter assay (EC50 ≈ 3 μM); necessary for normal Hh signaling; induces Smo accumulation in primary cilia; stimulates osteogenic differentiation of pluripotent bone marrow stromal cells via Hh and Notch

20(S)-hydroxy Cholesterol – 1 mg

Brand:
Cayman
CAS:
516-72-3
Storage:
-20
UN-No:
Non-Hazardous - /

20(S)-hydroxy Cholesterol is an allosteric agonist of the smoothened (Smo) receptor that activates the hedgehog (Hh) signaling pathway with an EC50 value of approxiately 3 μM in a gene transcription reporter assay using NIH3T3 cells.{21991} 20(S)-hydroxy Cholesterol is necessary for normal Hh signaling. It induces Smo accumulation in primary cilia, an early event in signaling, and binds to the extracellular, cysteine-rich domain of Smo.{21991,40043} 20(S)-hydroxy Cholesterol also stimulates osteogenic differentiation of pluripotent bone marrow stromal cells, a process mediated via Hh and Notch signaling.{40041,18498,40042}  

 

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Description

An allosteric Smo agonist; activates Hh signaling in a gene transcription reporter assay (EC50 ≈ 3 μM); necessary for normal Hh signaling; induces Smo accumulation in primary cilia; stimulates osteogenic differentiation of pluripotent bone marrow stromal cells via Hh and Notch

Formal name: cholest-5-ene-3β,20-diol

Synonyms:  20α-hydroxy Cholesterol

Molecular weight: 402.7

CAS: 516-72-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Sterol Lipids||Product Type|Biochemicals|Receptor Pharmacology|Allosteric Modulators||Research Area|Cell Biology|Cell Signaling|Hedgehog Signaling||Research Area|Cell Biology|Cell Signaling|Notch Signaling||Research Area|Endocrinology & Metabolism|Bone Growth & Remodeling||Research Area|Lipid Biochemistry|Sterol Lipids

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