A steroid glycoside with diverse biological activities; inhibits the replication of MHV-68 (IC50 = 2.77 μM) and the lytic replication of human gammaherpes virus in BC3 cells; reduces levels of NO

20(R)-Ginsenoside Rh2 – 10 mg

Brand:
Cayman
CAS:
112246-15-8
Storage:
-20
UN-No:
Non-Hazardous - /

20(R)-Ginsenoside Rh2 is a steroid glycoside originally isolated from P. ginseng and an isomer of 20(S)-ginsenoside Rh2 (Item No. 23390) that has diverse biological activities.{40332,42828,42829} It inhibits the replication of murine gammaherpes virus 68 (MHV-68; IC50 = 2.77 μM) and the lytic replication of human gammaherpes virus in BC3 cells.{40332} 20(R)-Ginsenoside Rh2 reduces levels of nitric oxide (NO), prostaglandin E2 (PGE2; Item No. 14010), reactive oxygen species (ROS), and pro-matrix metalloproteinase-9 (pro-MMP-9) in LPS-stimulated RAW 264.7 cells.{42828} It also reduces ROS production and MMP-9 and MMP-2 activity in HaCat human keratinocytes. 20(R)-Ginsenoside Rh2 (4 mg/kg) induces tumor cell apoptosis and reduces tumor growth in an H22 hepatocellular carcinoma mouse xenograft model.{42829}  

 

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SKU: 27300 - 10 mg Category:

Description

A steroid glycoside with diverse biological activities; inhibits the replication of MHV-68 (IC50 = 2.77 μM) and the lytic replication of human gammaherpes virus in BC3 cells; reduces levels of NO, PGE2, ROS, and pro-MMP-9 in LPS-stimulated RAW 264.7 cells; reduces ROS production and MMP-9 and MMP-2 activity in HaCat human keratinocytes; induces tumor cell apoptosis and reduces tumor growth in an H22 hepatocellular carcinoma mouse xenograft model at 4 mg/kg ,

Formal name: 12β,20R-dihydroxydammar-24-en-3β-yl β-D-glucopyranoside

Synonyms: 

Molecular weight: 622.9

CAS: 112246-15-8

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Natural Products|Glycosides||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Infectious Disease|Viral Diseases|HSV||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen

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