Description
A saponin that inhibits angiogenesis; dose-dependently reduces proliferation, capillary tube branching, and the expression of MMP-9 and MMP-2 at 0.001-1 μM in HUVECs; inhibits tumor cell invasion of MM1, B16FE7, OC-10, and PSN-1 cells in vitro by 89, 73.7, 84.2, and 59.1%, respectively, at 25 μM; reduces tumor volume, increases the tumor necrosis rate by approximately 16%, and increases survival in a human Lewis carcinoma mouse xenograft model at 20 mg/kg; reduces the total number of B16-BL6 and 26-M3.1 cell lung colonies in mice by 27 and 51%, respectively, at 100 μg, i.v.; reduces ear thickness of mice by 47.5% in an oxazolone-induced contact dermatitis model and reduces expression of COX-2, IL-4, IL-1, IFN, and TNF mRNA at 0.05% w/v, topical,
Formal name: 12β,20R-dihydroxydammar-24-en-3β-yl 2-O-β-D-glucopyranosyl-β-D-glucopyranoside
Synonyms: 20(R)-Propanaxadiol
Molecular weight: 785
CAS: 38243-03-7
Purity: ≥95%
Formulation: A crystalline solid
Product Type|Biochemicals|Natural Products|Saponins||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Immunology & Inflammation
