A CYP450 metabolite of arachidonic acid in the renal and cerebral vasculature; exhibits vasoconstrictor activity

20-HETE – 25 µg

Brand:
Cayman
CAS:
79551-86-3
Storage:
-20
UN-No:
De Minimis - 1170 / 3

20-HETE is a cytochrome P450 (CYP450) metabolite postulated to play an autacoid role in the renal and cerebral vasculature.{7827} In rat cerebral microvessels, 20-HETE is a vasoconstrictor that mediates pressure-induced autoregulatory vasoconstriction.{9023} 20-HETE is excreted mainly as the glucuronide conjugate. The concentration of free 20-HETE (20-40 pg/ml in human urine) is about 10-fold lower than the corresponding concentration of the 20-glucuronide.{1119} 20-HETE can be further metabolized by cyclooxygenase to 20-hydroxy PGG2 and 20-hydroxy PGH2.{380}  

 

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Description

A CYP450 metabolite of arachidonic acid in the renal and cerebral vasculature; exhibits vasoconstrictor activity

Formal name: 20-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoic acid

Synonyms:  20-hydroxy Arachidonic Acid

Molecular weight: 320.5

CAS: 79551-86-3

Purity: ≥98%

Formulation: A solution in ethanol

Product Type|Biochemicals|Lipids|Hydroxy/Hydroperoxy/ Epoxy/Oxo Eicosanoids||Research Area|Cardiovascular System|Vasculature|Vasoconstriction||Research Area|Lipid Biochemistry|Cytochrome P450 Pathways

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