An EPA metabolite; formed via ω-oxidation of EPA by CYP ω-oxidases

20-HEPE – 100 µg

Brand:
Cayman
CAS:
116477-57-7
Storage:
-20
UN-No:
Non-Hazardous - 1231 / 3

20-HEPE is a metabolite of eicosapentaenoic acid (EPA; Item Nos. 90110 | 21908 | 90110.1) that is formed via ω-oxidation of EPA by cytochrome P450 (CYP) ω-oxidases, including human CYP4F3B.{37628} It activates peroxisome proliferator-activated receptor α (PPARα) in COS-7 cells expressing a luciferase reporter when used at a concentration of 10 μM. 20-HEPE also activates murine transient receptor potential vanilloid receptor 1 (mTRPV1) in vitro but lacks antinociceptive activity in rats.{37629}  

 

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Description

An EPA metabolite; formed via ω-oxidation of EPA by CYP ω-oxidases, including human CYP4F3B; activates PPARα in COS-7 cells expressing a luciferase reporter at 10 μM; activates mTRPV1 in vitro

Formal name: 20-hydroxy-5Z,8Z,11Z,14Z,17Z-eicosapentaenoic acid

Synonyms: 

Molecular weight: 318.5

CAS: 116477-57-7

Purity: ≥95%

Formulation: A solution in methyl acetate

Product Type|Biochemicals|Ion Channel Modulation|Activators||Product Type|Biochemicals|Lipids|Hydroxy/Hydroperoxy/ Epoxy/Oxo Eicosanoids||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Lipid Biochemistry|Cytochrome P450 Pathways

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