An analog of PGF2α in which the ω-chain has been extended by the addition of two more methylene carbon atoms; exhibits a Ki value of 120 nM for the FP receptor

20-ethyl Prostaglandin F2α – 1 mg

Brand:
Cayman
CAS:
36950-85-3
Storage:
-20
UN-No:
De Minimis - 1231 / 3

20-ethyl Prostaglandin F2α (20-ethyl PGF2α) is an analog of PGF2α in which the ω-chain has been extended by the addition of two more methylene carbon atoms. It is therefore a modified version of the clinically approved glaucoma medication unoprostone.{8147} Unoprostone also contains lower side chain modifications (13,14-dihydro-15-keto) which severely limit its affinity for FP receptors, contributing to its lack of potency as a medication. 20-ethyl PGF2α retains the natural 15(S) allylic hydroxyl in the lower side chain, which may improve its potency as an intraocular hypotensive agent compared to unoprostone. The 2 carbon extension in 20-ethyl-PGF2α increases the Ki (120 nM) for the FP receptor from bovine corpus luteum only about 2.5-fold compared to PGF2α (50 nM).{11182} In vivo effects may be prolonged using 20-ethyl PGF2α, as the activity of 15-hydroxy PGDH using 20-ethyl PGF2α as a substrate is only 35% of the activity observed with PGF2α.{2309,11182}  

 

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Description

An analog of PGF2α in which the ω-chain has been extended by the addition of two more methylene carbon atoms; exhibits a Ki value of 120 nM for the FP receptor

Formal name: 9α,11α,15S-trihydroxy-20a,20b-dihomoprosta-5Z,13E-dien-1-oic acid

Synonyms:  20-ethyl PGF2α|ICI 74205

Molecular weight: 382.5

CAS: 36950-85-3

Purity: ≥98%

Formulation: A solution in methyl acetate

Product Type|Biochemicals|Lipids|Prostaglandins||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway

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