20-carboxy LTB4 is a metabolite of LTB4 in human neutrophils. In human leukocytes

20-carboxy Leukotriene B4 – 50 µg

Brand:
Cayman
CAS:
80434-82-8
Storage:
-20
UN-No:
De Minimis - 1170 / 3

20-carboxy LTB4 is a metabolite of LTB4 in human neutrophils. In human leukocytes, LTB4 is inactivated by the enzyme LTB4 20-hydroxylase. The resulting 20-hydroxy LTB4 is further oxidized to 20-carboxy LTB4.{377} LTB4 metabolism in isolated rat hepatocytes also results in production of 20-carboxy LTB4 along with other ω-oxidation products.{1032} The biological activity of 20-carboxy LTB4 is only about 2.6% compared to that of LTB4 in causing PMNL degranulation.{399}  

 

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Description

20-carboxy LTB4 is a metabolite of LTB4 in human neutrophils. In human leukocytes, LTB4 is inactivated by the enzyme LTB4 20-hydroxylase. The resulting 20-hydroxy LTB4 is further oxidized to 20-carboxy LTB4.{377} LTB4 metabolism in isolated rat hepatocytes also results in production of 20-carboxy LTB4 along with other ω-oxidation products.{1032} The biological activity of 20-carboxy LTB4 is only about 2.6% compared to that of LTB4 in causing PMNL degranulation.{399}

Formal name: 5S,12R-dihydroxy-6Z,8E,10E,14Z-eicosatetraene-1,20-dioic acid

Synonyms:  20-carboxy LTB4

Molecular weight: 366.5

CAS: 80434-82-8

Purity: ≥97%

Formulation: A solution in ethanol

Product Type|Biochemicals|Lipids|Leukotrienes||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Lipid Biochemistry|Lipoxygenase Pathways

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