An inhibitor of respiration in animals and bacteria; binds at the quinone reduction site of succinate:ubiquinone oxidoreductase (SQR; Complex II) in animals

2-Thenoyltrifluoroacetone – 50 g

Brand:
Cayman
CAS:
326-91-0
Storage:
-20
UN-No:
Non-Hazardous - /

2-Thenoyltrifluoroacetone (TTFA) is an inhibitor of respiration in animals and bacteria. In animals, TTFA binds at the quinone reduction site of succinate:ubiquinone oxidoreductase (SQR; Complex II), preventing ubiquinone from binding.{29181,21747} It inhibits NADH fumarate reductase in bacteria.{29182,29179} TTFA also inhibits photosystem II in plants and NADH-ubiquinone oxidoreductase of the virus Vibrio cholerae, decreasing cholera toxin production.{24939,29180} This compound is also a chelator of metals, including lanthanum, zirconium, hafnium, and neodymium.  

 

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Description

An inhibitor of respiration in animals and bacteria; binds at the quinone reduction site of succinate:ubiquinone oxidoreductase (SQR; Complex II) in animals, preventing ubiquinone from binding; inhibits NADH fumarate reductase in bacteria; inhibits photosystem II in plants

Formal name: 4,4,4-trifluoro-1-(2-thienyl)-1,3-butanedione

Synonyms:  NSC 405702|NSC 405703|NSC 405704|NSC 405705|NSC 405706|NSC 66544|TTFA

Molecular weight: 222.2

CAS: 326-91-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Oxidative Phosphorylation||Research Area|Cell Biology|Mitochondrial Biology||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases|Cholera||Research Area|Plant Biology

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