A fatty acid ester that potentiates the activity of other endocannabinoids

2-Palmitoyl Glycerol – 10 mg

Brand:
Cayman
CAS:
23470-00-0
Storage:
-80
UN-No:
Non-Hazardous - /

2-Arachidonoyl glycerol (2-AG; Item No. 62160) is an endogenous agonist of the CB1 and CB2 cannabinoid receptors. 2-Palmitoyl glycerol is a fatty acid ester that does not bind directly to cannabinoid receptors, nor inhibit adenylyl cyclase, but rather potentiates the activity of 2-AG (and other endocannabinoids) to bind to CB1 and CB2 and inhibit adenylyl cyclase.{9610} This “entourage” effect has been attributed to blockade of the breakdown and reuptake pathways that normally function to reduce endocannabinoid levels rapidly upon release.{9610} 2-Palmitoyl glycerol and related endogenous fatty acid derivatives have been shown to interact with endocannabinoids in the modulation of pain sensitivity.{29117}  

 

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Description

A fatty acid ester that potentiates the activity of other endocannabinoids, including 2-AG to bind to CB1 and CB2 and inhibit adenylyl cyclase; interacts with endocannabinoids in the modulation of pain sensitivity

Formal name: 2-hydroxy-1-(hydroxymethyl)ethyl ester hexadecanoic acid

Synonyms:  2-Hexadecanoyl Glycerol|2-Monopalmitin|2-PG|Glycerol-β-palmitate

Molecular weight: 330.5

CAS: 23470-00-0

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Glycerolipids||Research Area|Lipid Biochemistry|Glycerolipids||Research Area|Neuroscience|Cannabinoid Research|Endocannabinoids||Research Area|Neuroscience|Pain Research

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