A natural flavonoid; scavenges DPPH and ABTS radicals (IC50s = 3 and 3.5 μM

2”-O-Galloylhyperin – 10 mg

Brand:
Cayman
CAS:
53209-27-1
Storage:
-20
UN-No:
Non-Hazardous - /

2”-O-Galloylhyperin is a natural flavonoid that has been found in P. incarnata and has diverse biological activities, including antioxidant, anti-inflammatory, hepatoprotective, and transporter-inhibiting properties.{53103,53104,53105} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) and ABTS (Item No. 27317) radicals (IC50s = 3 and 3.5 μM, respectively).{53103} It also inhibits human organic anion transporting polypeptide 1B1 (OATP1B1; IC50 = 19 μM in HEK293 cells).{53104} 2”-O-Galloylhyperin (15 μM) decreases LPS-induced IL-6 and TNF-α cytokine production from mouse RAW 264.7 macrophages.{53105} It also decreases LPS-induced mortality and liver damage in a mouse model of septic shock when administered at a dose of 50 mg/kg.  

 

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SKU: 29086 - 10 mg Category:

Description

A natural flavonoid; scavenges DPPH and ABTS radicals (IC50s = 3 and 3.5 μM, respectively); inhibits human OATP1B1 (IC50 = 19 μM in HEK293 cells); decreases LPS-induced IL-6 and TNF-α cytokine production from mouse RAW 264.7 macrophages at 15 μM; decreases LPS-induced mortality and liver damage in a mouse model of septic shock at 50 mg/kg

Formal name: 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-[[2-O-(3,4,5-trihydroxybenzoyl)-β-D-galactopyranosyl]oxy]-4H-1-benzopyran-4-one

Synonyms:  Hyperin-2”-Gallate

Molecular weight: 616.5

CAS: 53209-27-1

Purity: ≥98%

Formulation: A crystalline solid

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